BIT-DST sponsored “Laboratory for Venom Peptidomics and Molecular Simulation (LVPMS)” established in 2014 and nested in the Biotechnology department, molecular characterizes toxic peptides and molecules obtained different venomous spies both in land and Sea. State of the art facilities are deployed for obtaining single molecules for therapeutic use. Molecular interactions between the lethal toxins and voltage gated channels with an expertise from both the expertise in International and Indian counterparts aim at developing isoform specific drugs. Various International and National collaboration is involved in this research.
|1. Venom Biology|
|2. Ion Channels and Electrophysiology.|
|4. Computational Biology and Bioinformatics.|
|5. Protein Chemistry and Structural Biology.|
|1. Test for the effectiveness of the isolated toxins from conotoxins, Indian spiders and scorpions.|
|2. To develop a antibody/Toxin/Sodium channel interaction database.|
|3. Molecular simulation on different modelled channel with toxin structures.|
|4. Bioinformatic approach to toxin/sodium channel structure-function relationship studies and through known Toxin/Nanobody interaction relationships.|
|5. To find the selectivity of the toxin with different sodium channel subtypes thereby opening avenue on subtype selective drugs.|
|1. To train manpower by guiding research scholars for research degrees in Toxin and Bioinformatics research.|
|2. To guide PG and UG students for their final year projects.|
Dr. B A Gowri Shankar, PhD.
Prof. P Gautam, Director and Head, Centre for Biotechnology, Anna University, Chennai.
Indo-Tunisian Project Jointly sponsored by Dept. of Science & Technology, Govt. of India and Ministry of Higher Education and Scientific Research of the Republic of Tunisia
Title : Toxin and voltage gated sodium channel interactions: A study on structure-activity relationships
Title : Toxin and voltage gated sodium channel interactions: a bioinformatic approach of structure-activity relationships
Indian PI: Dr. B A Gowri Shankar, BIT>
Tunisian PI: Prof. Rosa Lemmens Gruber, University of Vienna, Austria.
Sanction No. : INT/AUA /BMWF/P-14/2013, 04-06-2013 Budget: INR 3,82,100
Time Period: 2013 – 2015
|Articles in journals with peer review